The eTRANSAFE (Enhancing TRANslational SAFEty Assessment through Integrative Knowledge Management) project works to improve the efficiency of translational safety assessment approaches during the medicines discovery pipeline

New Challenges and Progress During the 12th CM

Important advances of the eTRANSAFE project were shared during the 12th Consortium Meeting held from June 17 to 18, 2021. Over 2 days, the members of the project spoke about the work carried out since the last meeting with encouraging results.

Virtual Control Groups: one step forward into the future of animal testing in toxicology

Historical control databases are established by many companies (i) enabling contextualization of results from single studies against previous studies performed under similar conditions, (ii) to properly design studies and/or (iii) to come up with quality control instruments. Although the use of historical control data in supporting inferences varies across different assays; one major opportunity is the derivation of so-called Virtual Control Groups (VCGs) for replacement of animals in the control groups and thus enabling a 3R strategy for future animal testing approaches.

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